Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Abstract Background The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is a complement regulatory protein inhi...

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Bibliographic Details
Main Authors: E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Bacterial meningitis
Pneumococcal meningitis
Complement system
Complement factor H
Anti-inflammatory therapy
Animal models
Online Access:https://doi.org/10.1186/s12974-019-1675-1

Internet

https://doi.org/10.1186/s12974-019-1675-1

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