Partial Depletion of Peripheral M1 Macrophages Reverses Motor Deficits in MPTP-Treated Mouse by Suppressing Neuroinflammation and Dopaminergic Neurodegeneration

Partial Depletion of Peripheral M1 Macrophages Reverses Motor Deficits in MPTP-Treated Mouse by Suppressing Neuroinflammation and Dopaminergic Neurodegeneration

Background: Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD). Inflammatory cytokines in the peripheral immune system can induce neuroinflammation in central nervous system (CNS). Whether the peripheral immune system is involved in PD is unclear. The pres...

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Bibliographic Details
Main Authors: Aijuan Yan, Yu Zhang, Jingya Lin, Lu Song, Xijin Wang, Zhenguo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
M1 macrophages
T cells
neuroinflammation
microglia
Parkinson's disease
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00160/full

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00160/full

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