The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

Aging is accompanied by disrupted information flow, resulting from accumulation of molecular mistakes. These mistakes ultimately give rise to debilitating disorders including skeletal muscle wasting, or sarcopenia. To derive a global metric of growing ‘disorderliness’ of aging muscle, we employed a...

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Bibliographic Details
Main Authors: Zachary Clemens, Sruthi Sivakumar, Abish Pius, Amrita Sahu, Sunita Shinde, Hikaru Mamiya, Nathaniel Luketich, Jian Cui, Purushottam Dixit, Joerg D Hoeck, Sebastian Kreuz, Michael Franti, Aaron Barchowsky, Fabrisia Ambrosio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
skeletal muscle
hallmarks of aging
klotho
muscle stem cells
sarcopenia
adeno-associated virus
Online Access:https://elifesciences.org/articles/61138

Internet

https://elifesciences.org/articles/61138

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