The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4+Foxp3+ Regulatory T Cells

The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4+Foxp3+ Regulatory T Cells

There is now compelling evidence that tumor necrosis factor (TNF) preferentially activates and expands CD4+Foxp3+ regulatory T cells (Tregs) through TNF receptor type II (TNFR2). However, it remains unclear which signaling transduction pathway(s) of TNFR2 is required for the stimulation of Tregs. Pr...

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Bibliographic Details
Main Authors: Tianzhen He, Shuoyang Liu, Shaokui Chen, Jingyi Ye, Xueqiang Wu, Zhaoxiang Bian, Xin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
tumor necrosis factor
TNF receptor type II
p38 MAPK
CD4+Foxp3+ regulatory T cells
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01556/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01556/full

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