Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynthesis pathway with ornithine decarboxylase (ODC) in...

Full description

Bibliographic Details
Main Authors: Rebecca R. Weicht, Chad R. Schultz, Dirk Geerts, Katie L. Uhl, André S. Bachmann
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Medical Sciences
Subjects:
cell differentiation
DFMO
ornithine decarboxylase
osteosarcoma
polyamines
Online Access:http://www.mdpi.com/2076-3271/6/3/65

Internet

http://www.mdpi.com/2076-3271/6/3/65

Similar Items