Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia

Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia

Objective: We aimed to understand the impact of dopamine receptor D4 (DRD4) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRD4 dampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density. Give...

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Bibliographic Details
Main Authors: P.M. Butler, W. Chiong, D.C. Perry, Z.A. Miller, E.D. Gennatas, J.A. Brown, L. Pasquini, A. Karydas, D. Dokuru, G. Coppola, V.E. Sturm, A.L. Boxer, M.L. Gorno-Tempini, H.J. Rosen, J.H. Kramer, B.L. Miller, W.W. Seeley
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S221315821930172X

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http://www.sciencedirect.com/science/article/pii/S221315821930172X

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