Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

Diets rich in saturated fatty acids (SFAs) produce a form of tissue inflammation driven by “metabolically activated” macrophages. We show that SFAs, when in excess, induce a unique transcriptional signature in both mouse and human macrophages that is enriched by a subset of ER stress markers, partic...

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Bibliographic Details
Main Authors: Megan M. Robblee, Charles C. Kim, Jess Porter Abate, Martin Valdearcos, Karin L.M. Sandlund, Meera K. Shenoy, Romain Volmer, Takao Iwawaki, Suneil K. Koliwad
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301747

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http://www.sciencedirect.com/science/article/pii/S2211124716301747

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