IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.

IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.

Receptor endocytosis is critical for cell signaling. IGF1R mediates an autocrine loop that is de-regulated in Ewing Sarcoma (ES) cells. Here we study the impact of IGF1R internalization, mediated by clathrin and caveolin-1 (CAV1), in ES signaling. We used clathrin and CAV1-siRNA to interfere in clat...

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Bibliographic Details
Main Authors: Ana Sofia Martins, José Luis Ordóñez, Ana Teresa Amaral, Frans Prins, Giuseppe Floris, Maria Debiec-Rychter, Pancras C W Hogendoorn, Enrique de Alava
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3096649?pdf=render

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http://europepmc.org/articles/PMC3096649?pdf=render

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