EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model

EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model

Abstract It was previously shown that EphB/ephrinB reverse signaling in retinal ganglion cells (RGCs) is activated and involved in RGC apoptosis in a rat chronic ocular hypertension (COH) model. In the present work, we first show that ephrinB/EphB forward signaling was activated in COH retinas, and...

Full description

Bibliographic Details
Main Authors: Shu-Ting Liu, Shu-Min Zhong, Xue-Yan Li, Feng Gao, Fang Li, Meng-Lu Zhang, Ke Zhu, Xing-Huai Sun, Xin Wang, Yanying Miao, Xiong-Li Yang, Zhongfeng Wang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Acta Neuropathologica Communications
Subjects:
ephrinB/EphB forward signaling
Retinal Müller cells
TNF-α
NR2B
Glaucoma
Online Access:http://link.springer.com/article/10.1186/s40478-018-0618-x

Internet

http://link.springer.com/article/10.1186/s40478-018-0618-x

Similar Items