Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. This study tested the hypothesis that FXR-mediated in...

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Bibliographic Details
Main Authors: Thomas Gautier, Willeke de Haan, Jacques Grober, Dan Ye, Matthias J. Bahr, Thierry Claudel, Niels Nijstad, Theo J.C. Van Berkel, Louis M. Havekes, Michael P. Manns, Stefan M. Willems, Pancras C.W. Hogendoorn, Laurent Lagrost, Folkert Kuipers, Miranda Van Eck, Patrick C.N. Rensen, Uwe J.F. Tietge
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Journal of Lipid Research
Subjects:
nuclear receptor
lipoproteins
bile acids
hepatocyte
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375350

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http://www.sciencedirect.com/science/article/pii/S0022227520375350

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