Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with <i>EGFR</i> Exon 20 Insertion Mutations

Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with <i>EGFR</i> Exon 20 Insertion Mutations

Besides platinum-based chemotherapy, no established treatment option exists for advanced non-small-cell lung cancer (NSCLC) patients with <i>EGFR</i> exon 20 (Ex20ins) insertion mutations. We sought to determine the clinical outcome of patients with this <i>EGFR</i> mutation...

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Bibliographic Details
Main Authors: Giulio Metro, Sara Baglivo, Guido Bellezza, Martina Mandarano, Alessio Gili, Giovanni Marchetti, Marco Toraldo, Carmen Molica, Maria Sole Reda, Francesca Romana Tofanetti, Annamaria Siggillino, Enrico Prosperi, Antonella Giglietti, Bruna Di Girolamo, Miriam Garaffa, Francesca Marasciulo, Vincenzo Minotti, Marco Gunnellini, Annalisa Guida, Monica Sassi, Angelo Sidoni, Fausto Roila, Vienna Ludovini
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
<i>EGFR</i> exon 20 insertion mutations (Ex20ins)
immune checkpoint blockade (ICB)
immunotherapy
non-small-cell lung cancer (NSCLC)
PD-L1
Online Access:https://www.mdpi.com/2073-4425/12/5/679

Internet

https://www.mdpi.com/2073-4425/12/5/679

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