Basing on uPAR-binding fragment to design chimeric antigen receptors triggers antitumor efficacy against uPAR expressing ovarian cancer cells

Basing on uPAR-binding fragment to design chimeric antigen receptors triggers antitumor efficacy against uPAR expressing ovarian cancer cells

Due to the success of chimeric antigen receptors (CARs) in hematological tumors, CARs are also being studied to treat solid tumors. Improving the ability of CARs to penetrate solid tumor tissues is one of the biggest challenges. As the most malignant cancer of the female reproductive system, the sur...

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Bibliographic Details
Main Authors: Liang Wang, Rulin Yang, Liping Zhao, Xiwen Zhang, Tianmin Xu, Manhua Cui
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
UPAR
Ovarian cancer
Chimeric antigen receptor
Effector to target ratio
Cytokines
Granzyme B
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219323674

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http://www.sciencedirect.com/science/article/pii/S0753332219323674

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