Many, but not all, lineage-specific genes can be explained by homology detection failure.

Genes for which homologs can be detected only in a limited group of evolutionarily related species, called "lineage-specific genes," are pervasive: Essentially every lineage has them, and they often comprise a sizable fraction of the group's total genes. Lineage-specific genes are oft...

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Bibliographic Details
Main Authors: Caroline M Weisman, Andrew W Murray, Sean R Eddy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000862