Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection

Influenza virus is among the most common causes of respiratory illness worldwide and can be complicated by secondary bacterial pneumonia, a frequent cause of mortality. When influenza virus infects the lung, the innate immune response is activated, and interferons and inflammatory mediators are rele...

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Bibliographic Details
Main Authors: Radha Gopal, Angelico Mendy, Michael A. Marinelli, Lacee J. Richwalls, Philip J. Seger, Shivani Patel, Kevin J. McHugh, Helen E. Rich, Jennifer A. Grousd, Erick Forno, John F. Alcorn
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Viruses
Subjects:
lung
pneumonia
MRSA
PPARγ agonist
rosiglitazone
neutrophils
cytokines
chemokines
Online Access:https://www.mdpi.com/1999-4915/11/6/505

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https://www.mdpi.com/1999-4915/11/6/505

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