Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage

Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage

Kidney damage is markedly accelerated by high-salt (HS) intake in stroke-prone spontaneously hypertensive rats (SHRSP). Epoxyeicosatrienoic acids (EETs) are epoxygenase products of arachidonic acid which possess vasodepressor, natriuretic and anti-inflammatory activities. We examined whether up-regu...

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Bibliographic Details
Main Authors: Jing eLi, Charles T. Stier, Praveen N. Chander, Vijaya L. Manthati, John R. Falck, Mairead A. Carroll
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Pharmacology
Subjects:
Clofibrate
Proteinuria
renal damage
Epoxyeicosatrienoic acids
SHRSP
high-salt intake
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00187/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00187/full

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