AHR:IKAROS Interaction Promotes Platelet Biogenesis in Response to SR1

AHR:IKAROS Interaction Promotes Platelet Biogenesis in Response to SR1

In vitro, the differentiation of megakaryocytes (MKs) is improved by aryl-hydrocarbon receptor (AHR) antagonists such as StemRegenin 1 (SR1), an effect physiologically recapitulated by the presence of stromal mesenchymal cells (MSC). This inhibition promotes the amplification of a CD34<sup>+&l...

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Bibliographic Details
Main Authors: Lea Mallo, Valentin Do Do Sacramento, Christian Gachet, Susan Chan, Philippe Kastner, François Lanza, Henri de la de la Salle, Catherine Strassel
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Reports
Subjects:
AHR
IKAROS
megakaryocytes
platelet production
Online Access:https://www.mdpi.com/2571-841X/4/1/7

Internet

https://www.mdpi.com/2571-841X/4/1/7

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