Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis

Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis

Abstract Objective The goal of this study was to explore the role of bradykinins and bradykinin 1 receptor (B1R) in murine lupus nephritis. Methods C57BL/6 and MRL/lpr mice were compared for renal expression of B1R and B2R by western blot and immunohistochemistry. MRL/lpr lupus-prone mice were admin...

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Bibliographic Details
Main Authors: Ling Qin, Yong Du, Huihua Ding, Anam Haque, John Hicks, Claudia Pedroza, Chandra Mohan
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Arthritis Research & Therapy
Subjects:
Bradykinins
Hypertension
Lupus nephritis
Kallikrein
Online Access:http://link.springer.com/article/10.1186/s13075-018-1774-x

Internet

http://link.springer.com/article/10.1186/s13075-018-1774-x

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