PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Abstract Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superflu...

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Bibliographic Details
Main Authors: Peter M. J. Quinn, Paula I. Moreira, António Francisco Ambrósio, C. Henrique Alves
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Acta Neuropathologica Communications
Subjects:
PINK1
PARKIN
Mitophagy
Neurodegeneration
Alzheimer’s disease
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s40478-020-01062-w

Internet

http://link.springer.com/article/10.1186/s40478-020-01062-w

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