LSEC Fenestrae Are Preserved Despite Pro-inflammatory Phenotype of Liver Sinusoidal Endothelial Cells in Mice on High Fat Diet

LSEC Fenestrae Are Preserved Despite Pro-inflammatory Phenotype of Liver Sinusoidal Endothelial Cells in Mice on High Fat Diet

Healthy liver sinusoidal endothelial cells (LSECs) maintain liver homeostasis, while LSEC dysfunction was suggested to coincide with defenestration. Here, we have revisited the relationship between LSEC pro-inflammatory response, defenestration, and impairment of LSEC bioenergetics in non-alcoholic...

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Bibliographic Details
Main Authors: Edyta Kus, Patrycja Kaczara, Izabela Czyzynska-Cichon, Karolina Szafranska, Bartlomiej Zapotoczny, Agnieszka Kij, Agnieszka Sowinska, Jerzy Kotlinowski, Lukasz Mateuszuk, Elzbieta Czarnowska, Marek Szymonski, Stefan Chlopicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
LSEC metabolism
LSEC inflammation
LSEC porosity
non-alcoholic fatty liver disease
liver steatosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00006/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00006/full

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