Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons

Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons

While the exact role of β1 subunit-containing GABA-A receptors (GABARs) in brain function is not well understood, altered expression of the β1 subunit gene (GABRB1) is associated with neurological and neuropsychiatric disorders. In particular, down-regulation of β1 subunit levels is observed in brai...

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Bibliographic Details
Main Authors: Zhuting Li, Meaghan Cogswell, Kathryn Hixson, Amy R. Brooks-Kayal, Shelley J. Russek
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GABA-A receptor
GABRB1
NRF-1
cortical neurons
activity-dependent
mitochondrial biogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00285/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00285/full

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