Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
Abstract Background Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial to understand how the Aβ/αSYN aggregates can be cleared....
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-06-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-021-02158-3 |