Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Abstract Background Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial to understand how the Aβ/αSYN aggregates can be cleared....

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Bibliographic Details
Main Authors: Jinar Rostami, Tobias Mothes, Mahshad Kolahdouzan, Olle Eriksson, Mohsen Moslem, Joakim Bergström, Martin Ingelsson, Paul O’Callaghan, Luke M. Healy, Anna Falk, Anna Erlandsson
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Parkinson’s disease
α-Synuclein
Crosstalk
Amyloid-β
Astrocyte
Online Access:https://doi.org/10.1186/s12974-021-02158-3

Internet

https://doi.org/10.1186/s12974-021-02158-3

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