Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis

Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis

In multiple sclerosis (MS), monoaminergic systems are altered as a result of both inflammation-dependent reduced synthesis and direct structural damage. Aberrant monoaminergic neurotransmission is increasingly considered a major contributor to fatigue pathophysiology. In this study, we aimed to comp...

Full description

Bibliographic Details
Main Authors: Tiziana Carandini, Matteo Mancini, Iulia Bogdan, Charlotte L. Rae, Andrew W. Barritt, Arjun Sethi, Neil Harrison, Waqar Rashid, Elio Scarpini, Daniela Galimberti, Marco Bozzali, Mara Cercignani
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Multiple sclerosis
Monoaminergic system
Tractography
Fixel-based analysis
Fatigue
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158221000310

Internet

http://www.sciencedirect.com/science/article/pii/S2213158221000310

Similar Items