Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.

Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.

Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic compartments and loaded to major histocompatibility complex (MHC) class II molecules...

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Bibliographic Details
Main Authors: Fang Zou, Nadja Schäfer, David Palesch, Ruth Brücken, Alexander Beck, Marcin Sienczyk, Hubert Kalbacher, ZiLin Sun, Bernhard O Boehm, Timo Burster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3151250?pdf=render

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http://europepmc.org/articles/PMC3151250?pdf=render

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