High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

Summary: Organoids allow the recapitulation of intestinal homeostasis and cancerogenesis in vitro; however, RNA sequencing (RNA-seq)-based methods for drug screens are missing. We develop targeted organoid sequencing (TORNADO-seq), a high-throughput, high-content drug discovery platform that uses ta...

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Bibliographic Details
Main Authors: Maxim Norkin, Paloma Ordóñez-Morán, Joerg Huelsken
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003405