Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics

Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stre...

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Bibliographic Details
Main Authors: Qing Lu, Evgeny A. Zemskov, Xutong Sun, Hui Wang, Manivannan Yegambaram, Xiaomin Wu, Alejandro Garcia-Flores, Shanshan Song, Haiyang Tang, Archana Kangath, Gabriela Zubiate Cabanillas, Jason X.-J. Yuan, Ting Wang, Jeffrey R. Fineman, Stephen M. Black
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
VILI
TRPV4
PKCα
eNOS
Mitochondrial bioenergetics
Barrier permeability
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309903

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http://www.sciencedirect.com/science/article/pii/S2213231720309903

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