Generation of Monoclonal Antibodies Specific for Native LL37 and Citrullinated LL37 That Discriminate the Two LL37 Forms in the Skin and Circulation of Cutaneous/Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

Generation of Monoclonal Antibodies Specific for Native LL37 and Citrullinated LL37 That Discriminate the Two LL37 Forms in the Skin and Circulation of Cutaneous/Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

Human cathelicidin LL37 is a cationic antimicrobial peptide active against bacteria and viruses and exerting immune modulatory functions. LL37 can be also a target of autoreactive B- and T-lymphocytes in autoimmune settings. Irreversible post-translational modifications, such as citrullination and c...

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Bibliographic Details
Main Authors: Roberto Lande, Raffaella Palazzo, Philippe Hammel, Immacolata Pietraforte, Isabelle Surbeck, Michel Gilliet, Carlo Chizzolini, Loredana Frasca
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Antibodies
Subjects:
synthetic monoclonal antibodies
autoimmunity
protein post-translational modification (PTM), antimicrobial peptides
Online Access:https://www.mdpi.com/2073-4468/9/2/14

Internet

https://www.mdpi.com/2073-4468/9/2/14

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