The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction
Abstract Coronavirus disease 2019 (COVID-19) is regarded as an endothelial disease (endothelialitis) with its patho-mechanism being incompletely understood. Emerging evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ injuries. Thus, pharmaco...
Main Authors: | Suowen Xu, Yujie Liu, Yu Ding, Sihui Luo, Xueying Zheng, Xiumei Wu, Zhenghong Liu, Iqra Ilyas, Suyu Chen, Shuxin Han, Peter J. Little, Mukesh K. Jain, Jianping Weng |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-07-01
|
Series: | Signal Transduction and Targeted Therapy |
Online Access: | https://doi.org/10.1038/s41392-021-00690-5 |
Similar Items
-
Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
by: Yanni Xu, et al.
Published: (2017-07-01) -
S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension
by: Yiqian Ban, et al.
Published: (2019-02-01) -
Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship
by: Peter J. Little, et al.
Published: (2021-06-01) -
Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
by: Miguel Alejandro Lopez‐Ramirez, et al.
Published: (2021-05-01) -
Telomerase activator1: a zinc-finger protein that acts synergistically with auxin to control telomerase expression in Arabidopsis thaliana
by: Ren, Shuxin
Published: (2006)