Evolutionary Protection of Krüppel-Like Factors 2 and 4 in the Development of the Mature Hemovascular System

by David R. Sweet, David R. Sweet, David R. Sweet, Cherry Lam, Mukesh K. Jain, Mukesh K. Jain
Published 2021-05-01

KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

by Domenick A. Prosdocimo, Jenine E. John, Lilei Zhang, Elizabeth S. Efraim, Rongli Zhang, Xudong Liao, Mukesh K. Jain
Published 2015-01-01

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

by Ye Xiong, Jerry B. Lingrel, Marcel Wuthrich, Bruce S. Klein, Neelakantan T. Vasudevan, Mukesh K. Jain, Mariam George, George S. Deepe
Published 2016-06-01

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects

by Yuanyuan Zhao, Xiaoyan Sun, Di Hu, Domenick A. Prosdocimo, Charles Hoppel, Mukesh K. Jain, Rajesh Ramachandran, Xin Qi
Published 2019-03-01

Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential

by David R. Sweet, David R. Sweet, Liyan Fan, Liyan Fan, Paishiun N. Hsieh, Paishiun N. Hsieh, Mukesh K. Jain
Published 2018-02-01

Adipose KLF15 Controls Lipid Handling to Adapt to Nutrient Availability

by Keiichiro Matoba, Yuan Lu, Rongli Zhang, Eric R. Chen, Panjamaporn Sangwung, Benlian Wang, Domenick A. Prosdocimo, Mukesh K. Jain
Published 2017-12-01

KLF15 Establishes the Landscape of Diurnal Expression in the Heart

by Lilei Zhang, Domenick A. Prosdocimo, Xiaodong Bai, Chen Fu, Rongli Zhang, Frank Campbell, Xudong Liao, Jeff Coller, Mukesh K. Jain
Published 2015-12-01

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

by Suowen Xu, Yujie Liu, Yu Ding, Sihui Luo, Xueying Zheng, Xiumei Wu, Zhenghong Liu, Iqra Ilyas, Suyu Chen, Shuxin Han, Peter J. Little, Mukesh K. Jain, Jianping Weng
Published 2021-07-01

Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.

by Keiki Sugi, Paishiun N Hsieh, Olga Ilkayeva, Shamanthika Shelkay, Bridget Moroney, Palvir Baadh, Browning Haynes, Megan Pophal, Liyan Fan, Christopher B Newgard, Domenick A Prosdocimo, Mukesh K Jain
Published 2018-01-01

Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics

by Rengasamy Palanivel, Vinesh Vinayachandran, Shyam Biswal, Jeffrey A. Deiuliis, Roshan Padmanabhan, Bongsoo Park, Roopesh Singh Gangwar, Jared C. Durieux, Elaine Ann Ebreo Cara, Lopa Das, Graham Bevan, Zahi A. Fayad, Ahmed Tawakol, Mukesh K. Jain, Sujata Rao, Sanjay Rajagopalan
Published 2020-11-01

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

by Paishiun N. Hsieh, Guangjin Zhou, Yiyuan Yuan, Rongli Zhang, Domenick A. Prosdocimo, Panjamaporn Sangwung, Anna H. Borton, Evgenii Boriushkin, Anne Hamik, Hisashi Fujioka, Ciaran E. Fealy, John P. Kirwan, Maureen Peters, Yuan Lu, Xudong Liao, Diana Ramírez-Bergeron, Zhaoyang Feng, Mukesh K. Jain
Published 2017-10-01

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.

by Dae Young Jung, Umadevi Chalasani, Ning Pan, Randall H Friedline, Domenick A Prosdocimo, Minwoo Nam, Yoshihiro Azuma, Rajanikanth Maganti, Kristine Yu, Ashish Velagapudi, Bryan O'Sullivan-Murphy, Juliano L Sartoretto, Mukesh K Jain, Marcus P Cooper, Fumihiko Urano, Jason K Kim, Susan Gray
Published 2013-01-01

Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation

by David R. Sweet, Neelakantan T. Vasudevan, Liyan Fan, Chloe E. Booth, Komal S. Keerthy, Xudong Liao, Vinesh Vinayachandran, Yoichi Takami, Derin Tugal, Nikunj Sharma, E. Ricky Chan, Lilei Zhang, Yulan Qing, Stanton L. Gerson, Chen Fu, Anthony Wynshaw-Boris, Panjamaporn Sangwung, Lalitha Nayak, Paul Holvoet, Keiichiro Matoba, Yuan Lu, Guangjin Zhou, Mukesh K. Jain
Published 2020-11-01

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

by Lisa M. Walter, Marc-Olivier Deguise, Katharina E. Meijboom, Corinne A. Betts, Nina Ahlskog, Tirsa L.E. van Westering, Gareth Hazell, Emily McFall, Anna Kordala, Suzan M. Hammond, Frank Abendroth, Lyndsay M. Murray, Hannah K. Shorrock, Domenick A. Prosdocimo, Saptarsi M. Haldar, Mukesh K. Jain, Thomas H. Gillingwater, Peter Claus, Rashmi Kothary, Matthew J.A. Wood, Melissa Bowerman
Published 2018-05-01

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

by Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Xiaoying Piao, Naoki Toya, Yukari Oya, Akito Shikama, Ayako Takarada, Yukari Masuda, Makiko Nishi, Midori Kubota, Yoshihiko Izumida, Takashi Yamamoto, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Osamu Urayama, Yasushi Kawakami, Yoko Iizuka, Takanari Gotoda, Keiji Itaka, Kazunori Kataoka, Ryozo Nagai, Takashi Kadowaki, Nobuhiro Yamada, Yuan Lu, Mukesh K. Jain, Hitoshi Shimano
Published 2016-08-01