Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1.

by Naomi M Walsh, Marcel Wuthrich, Huafeng Wang, Bruce Klein, Christina M Hull
Published 2017-01-01

Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells.

by Som Gowda Nanjappa, Erika Heninger, Marcel Wüthrich, David Joseph Gasper, Bruce S Klein
Published 2012-01-01

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

by Andrew L. Garfoot, Qian Shen, Marcel Wuthrich, Bruce S. Klein, Chad A. Rappleye
Published 2016-04-01

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

by Som Gowda Nanjappa, Nydiaris Hernández-Santos, Kevin Galles, Marcel Wüthrich, M Suresh, Bruce S Klein
Published 2015-09-01

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

by Ye Xiong, Jerry B. Lingrel, Marcel Wuthrich, Bruce S. Klein, Neelakantan T. Vasudevan, Mukesh K. Jain, Mariam George, George S. Deepe
Published 2016-06-01

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells.

by Som Gowda Nanjappa, Andrew J McDermott, J Scott Fites, Kevin Galles, Marcel Wüthrich, George S Deepe, Bruce S Klein
Published 2017-05-01

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus.

by Naomi M Walsh, Michael R Botts, Andrew J McDermott, Sébastien C Ortiz, Marcel Wüthrich, Bruce Klein, Christina M Hull
Published 2019-06-01

Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination.

by Huafeng Wang, Taek-Jin Lee, Scott J Fites, Richard Merkhofer, Robert Zarnowski, Tristan Brandhorst, Kevin Galles, Bruce Klein, Marcel Wüthrich
Published 2017-08-01

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

by Gregory C. Kujoth, Thomas D. Sullivan, Richard Merkhofer, Taek-Jin Lee, Huafeng Wang, Tristan Brandhorst, Marcel Wuthrich, Bruce S. Klein, Joseph Heitman
Published 2018-04-01

O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures

by Andrew L. Garfoot, Kristie D. Goughenour, Marcel Wuthrich, Murugesan V. S. Rajaram, Larry S. Schlesinger, Bruce S. Klein, Chad A. Rappleye, J. Andrew Alspaugh
Published 2018-01-01

Structure and function of a fungal adhesin that binds heparin and mimics thrombospondin-1 by blocking T cell activation and effector function.

by T Tristan Brandhorst, René Roy, Marcel Wüthrich, Som Nanjappa, Hanna Filutowicz, Kevin Galles, Marco Tonelli, Darrell R McCaslin, Kenneth Satyshur, Bruce Klein
Published 2013-01-01

Novel strategies to enhance vaccine immunity against coccidioidomycosis.

by Garry T Cole, Chiung-Yu Hung, Sam D Sanderson, Brady J Hurtgen, Marcel Wüthrich, Bruce S Klein, George S Deepe, Gary R Ostroff, Stuart M Levitz
Published 2013-01-01

Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage...

by Isaque Medeiros Siqueira, Marcel Wüthrich, Mengyi Li, Huafeng Wang, Lucas de Oliveira Las-Casas, Raffael Júnio Araújo de Castro, Bruce Klein, Anamelia Lorenzetti Bocca
Published 2020-06-01

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

by Huafeng Wang, Mengyi Li, Chiung Yu Hung, Meenal Sinha, Linda M Lee, Darin L Wiesner, Vanessa LeBert, Tassanee Lerksuthirat, Kevin Galles, Marulasiddappa Suresh, Anthony L DeFranco, Clifford A Lowell, Bruce S Klein, Marcel Wüthrich
Published 2016-08-01

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense

by Philipp Wiemann, Adi Perevitsky, Fang Yun Lim, Yana Shadkchan, Benjamin P. Knox, Julio A. Landero Figueora, Tsokyi Choera, Mengyao Niu, Andrew J. Steinberger, Marcel Wüthrich, Rachel A. Idol, Bruce S. Klein, Mary C. Dinauer, Anna Huttenlocher, Nir Osherov, Nancy P. Keller
Published 2017-05-01

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense

by Philipp Wiemann, Adi Perevitsky, Fang Yun Lim, Yana Shadkchan, Benjamin P. Knox, Julio A. Landero Figueora, Tsokyi Choera, Mengyao Niu, Andrew J. Steinberger, Marcel Wüthrich, Rachel A. Idol, Bruce S. Klein, Mary C. Dinauer, Anna Huttenlocher, Nir Osherov, Nancy P. Keller
Published 2017-06-01

Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)

by Tonie E. Rocke, Brock Kingstad-Bakke, Marcel Wüthrich, Ben Stading, Rachel C. Abbott, Marcos Isidoro-Ayza, Hannah E. Dobson, Lucas dos Santos Dias, Kevin Galles, Julia S. Lankton, Elizabeth A. Falendysz, Jeffrey M. Lorch, J. Scott Fites, Jaime Lopera-Madrid, J. Paul White, Bruce Klein, Jorge E. Osorio
Published 2019-05-01

Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity.

by Lucas Dos Santos Dias, Hannah E Dobson, Brock Kingstad Bakke, Gregory C Kujoth, Junfeng Huang, Elaine M Kohn, Cleison Ledesma Taira, Huafeng Wang, Nitin T Supekar, J Scott Fites, Daisy Gates, Christina L Gomez, Charles A Specht, Stuart M Levitz, Parastoo Azadi, Lingjun Li, Marulasiddappa Suresh, Bruce S Klein, Marcel Wüthrich
Published 2021-03-01