Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi

by Richard M. Merkhofer, Bruce S. Klein, Bruce S. Klein, Bruce S. Klein, Bruce S. Klein
Published 2020-02-01

Improving on Defaults: Helping Pension Participants Manage Financial Market Risk in Target Date Funds

by John A. Turner, Bruce W. Klein
Published 2021-04-01

Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of Blastomyces

by Joseph A. McBride, Gregory M. Gauthier, Bruce S. Klein
Published 2019-01-01

Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells.

by Som Gowda Nanjappa, Erika Heninger, Marcel Wüthrich, David Joseph Gasper, Bruce S Klein
Published 2012-01-01

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

by Andrew L. Garfoot, Qian Shen, Marcel Wuthrich, Bruce S. Klein, Chad A. Rappleye
Published 2016-04-01

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

by Som Gowda Nanjappa, Nydiaris Hernández-Santos, Kevin Galles, Marcel Wüthrich, M Suresh, Bruce S Klein
Published 2015-09-01

Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay.

by Brad Tebbets, Douglas Stewart, Stephanie Lawry, Jeniel Nett, Andre Nantel, David Andes, Bruce S Klein
Published 2012-01-01

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

by Ye Xiong, Jerry B. Lingrel, Marcel Wuthrich, Bruce S. Klein, Neelakantan T. Vasudevan, Mukesh K. Jain, Mariam George, George S. Deepe
Published 2016-06-01

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells.

by Som Gowda Nanjappa, Andrew J McDermott, J Scott Fites, Kevin Galles, Marcel Wüthrich, George S Deepe, Bruce S Klein
Published 2017-05-01

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

by Gregory C. Kujoth, Thomas D. Sullivan, Richard Merkhofer, Taek-Jin Lee, Huafeng Wang, Tristan Brandhorst, Marcel Wuthrich, Bruce S. Klein, Joseph Heitman
Published 2018-04-01

O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures

by Andrew L. Garfoot, Kristie D. Goughenour, Marcel Wuthrich, Murugesan V. S. Rajaram, Larry S. Schlesinger, Bruce S. Klein, Chad A. Rappleye, J. Andrew Alspaugh
Published 2018-01-01

Novel strategies to enhance vaccine immunity against coccidioidomycosis.

by Garry T Cole, Chiung-Yu Hung, Sam D Sanderson, Brady J Hurtgen, Marcel Wüthrich, Bruce S Klein, George S Deepe, Gary R Ostroff, Stuart M Levitz
Published 2013-01-01

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

by J Scott Fites, Michael Gui, John F Kernien, Paige Negoro, Zeina Dagher, David B Sykes, Jeniel E Nett, Michael K Mansour, Bruce S Klein
Published 2018-05-01

SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis.

by Gregory M Gauthier, Thomas D Sullivan, Sergio S Gallardo, T Tristan Brandhorst, Amber J Vanden Wymelenberg, Christina A Cuomo, Garret Suen, Cameron R Currie, Bruce S Klein
Published 2010-04-01

The Known Unknowns of the Immune Response to <i>Coccidioides</i>

by Rebecca A. Ward, George R. Thompson, Alexandra-Chloé Villani, Bo Li, Michael K. Mansour, Marcel Wuethrich, Jenny M. Tam, Bruce S. Klein, Jatin M. Vyas
Published 2021-05-01

Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus

by Richard M. Merkhofer, Mary B. O’Neill, Donny Xiong, Nydiaris Hernandez-Santos, Hannah Dobson, J. Scott Fites, Abigail C. Shockey, Marcel Wuethrich, Caitlin S. Pepperell, Bruce S. Klein
Published 2019-06-01

Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs

by Xuequn Xu, Ginger M. Pocock, Akshat Sharma, Stephen L. Peery, J. Scott Fites, Laura Felley, Robert Zarnowski, Douglas Stewart, Erwin Berthier, Bruce S. Klein, Nathan M. Sherer, Jenny E. Gumperz
Published 2016-09-01

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

by Huafeng Wang, Mengyi Li, Chiung Yu Hung, Meenal Sinha, Linda M Lee, Darin L Wiesner, Vanessa LeBert, Tassanee Lerksuthirat, Kevin Galles, Marulasiddappa Suresh, Anthony L DeFranco, Clifford A Lowell, Bruce S Klein, Marcel Wüthrich
Published 2016-08-01

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense

by Philipp Wiemann, Adi Perevitsky, Fang Yun Lim, Yana Shadkchan, Benjamin P. Knox, Julio A. Landero Figueora, Tsokyi Choera, Mengyao Niu, Andrew J. Steinberger, Marcel Wüthrich, Rachel A. Idol, Bruce S. Klein, Mary C. Dinauer, Anna Huttenlocher, Nir Osherov, Nancy P. Keller
Published 2017-05-01

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense

by Philipp Wiemann, Adi Perevitsky, Fang Yun Lim, Yana Shadkchan, Benjamin P. Knox, Julio A. Landero Figueora, Tsokyi Choera, Mengyao Niu, Andrew J. Steinberger, Marcel Wüthrich, Rachel A. Idol, Bruce S. Klein, Mary C. Dinauer, Anna Huttenlocher, Nir Osherov, Nancy P. Keller
Published 2017-06-01