LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions

LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions

Abstract Background Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differentiation of rat bone marrow MSCs (rMSCs); however, the regulatory mech...

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Bibliographic Details
Main Authors: Xiaozhong Zhou, Wangyang Xu, Yeyang Wang, Hui Zhang, Li Zhang, Chao Li, Shun Yao, Zixiang Huang, Lishan Huang, Dixin Luo
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
Mesenchymal stem cells
Chondrogenic differentiation
Hypoxic condition
miR-127-5p
GREM2
DNM3OS
Online Access:https://doi.org/10.1186/s11658-021-00269-6

Internet

https://doi.org/10.1186/s11658-021-00269-6

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