RNA Interference in Mammalia Cells by RNA-3’-PNA Chimeras

RNA Interference in Mammalia Cells by RNA-3’-PNA Chimeras

The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in their therapeutic applications. Chemical modifications are introduced into siRNAs to optimize the potency, the stability and the pharmacokinetic properties in vivo. Here, we synthesize and test the effe...

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Bibliographic Details
Main Authors: Anna Messere, Aniello Russo, Benedetto Di Blasio, Vincenzo Salvatore, Giovanna Milano, Loredana Moggio, Nicoletta Potenza
Format: Article
Language:English
Published: MDPI AG 2008-03-01
Series:International Journal of Molecular Sciences
Subjects:
modified siRNA
RNA interference
RNA-PNA chimeras
Peptide Nucleic Acids
RNA.
Online Access:http://www.mdpi.com/1422-0067/9/3/299/

Internet

http://www.mdpi.com/1422-0067/9/3/299/

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