Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats

Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats

Flupirtine, a nonopioid analgesic drug, is effective in treating neonatal seizures. However, its brain delivery and pharmacokinetics are unknown in neonatal mammals. The purpose of this study was to determine the pharmacokinetics of flupirtine and the formation of its active metabolite D-13223 in va...

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Bibliographic Details
Main Authors: Madhoosudan A. Patil, Brock A. Matter, Yogendra H. Raol, David W. A. Bourne, Ryan A. Kelley, Uday B. Kompella
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
flupirtine
D-13223
brain delivery
drug metabolism
Online Access:https://www.mdpi.com/1999-4923/10/4/281

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https://www.mdpi.com/1999-4923/10/4/281

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