A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice.
Transgenes flanked by loxP sites have been widely used to generate transgenic mice where the transgene expression can be controlled spatially and temporally by Cre recombinase. Data from this approach has led to important conclusions in cancer, neurodevelopment and neurodegeneration. Using this appr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-05-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3091857?pdf=render |