Development of non-viral vehicles for targeted gene transfer into microglia via the integrin receptor CD11b

Development of non-viral vehicles for targeted gene transfer into microglia via the integrin receptor CD11b

Microglial activation is a central event in neurodegeneration. Novel technologies are sought for that specifically manipulate microglial function in order to delineate their role in onset and progression of neuropathologies. We investigated for the first time whether non-viral gene delivery based on...

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Bibliographic Details
Main Authors: Markus eSmolny, Mary-Louise eRogers, Anthony eShafton, Robert Archer Rush, Martin James Stebbing
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Microglia
Phagocytosis
Respiratory Burst
CD11b
non-viral vectors
Polyethyleneimine (PEI)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00079/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00079/full

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