Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V

Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V

There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes in P. falciparum populations in Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections imported to the United Kingdom from Nigeria. To...

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Bibliographic Details
Main Authors: Mary C. Oguike, Catherine O. Falade, Elvis Shu, Izehiuwa G. Enato, Ismaila Watila, Ebenezer S. Baba, Jane Bruce, Jayne Webster, Prudence Hamade, Sylvia Meek, Daniel Chandramohan, Colin J. Sutherland, David Warhurst, Cally Roper
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Sulfadoxine-pyrimethamine
dhps
dhfr
mutations
Nigeria
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320716300197

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http://www.sciencedirect.com/science/article/pii/S2211320716300197

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