Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer

Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is the most intractable cancer in women with a high risk of metastasis. While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a...

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Bibliographic Details
Main Authors: Woong Sub Byun, Won Kyung Kim, Hae Ju Han, Hwa-Jin Chung, Kyungkuk Jang, Han Sun Kim, Sunghwa Kim, Donghwa Kim, Eun Seo Bae, Sunghyouk Park, Jeeyeon Lee, Hyeung-geun Park, Sang Kook Lee
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770519300890

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http://www.sciencedirect.com/science/article/pii/S2372770519300890

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