A Pathway Switch Directs BAFF Signaling to Distinct NFκB Transcription Factors in Maturing and Proliferating B Cells

A Pathway Switch Directs BAFF Signaling to Distinct NFκB Transcription Factors in Maturing and Proliferating B Cells

BAFF, an activator of the noncanonical NFκB pathway, provides critical survival signals during B cell maturation and contributes to B cell proliferation. We found that the NFκB family member RelB is required ex vivo for B cell maturation, but cRel is required for proliferation. Combined molecular ne...

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Bibliographic Details
Main Authors: Jonathan V. Almaden, Rachel Tsui, Yi C. Liu, Harry Birnbaum, Maxim N. Shokhirev, Kim A. Ngo, Jeremy C. Davis-Turak, Dennis Otero, Soumen Basak, Robert C. Rickert, Alexander Hoffmann
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009905

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http://www.sciencedirect.com/science/article/pii/S2211124714009905

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