PCSK9 Regulates Nox2-Mediated Platelet Activation via CD36 Receptor in Patients with Atrial Fibrillation

PCSK9 Regulates Nox2-Mediated Platelet Activation via CD36 Receptor in Patients with Atrial Fibrillation

Background: High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) is predictive of cardiovascular events (CVEs) in atrial fibrillation (AF). We hypothesized that PCSK9 may directly induce platelet activation (PA). Methods: We measured platelet aggregation, recruitment, Thromboxane B2 (TxB2...

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Bibliographic Details
Main Authors: Vittoria Cammisotto, Daniele Pastori, Cristina Nocella, Simona Bartimoccia, Valentina Castellani, Cinzia Marchese, Antonio Sili Scavalli, Evaristo Ettorre, Nicola Viceconte, Francesco Violi, Pasquale Pignatelli, Roberto Carnevale
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Antioxidants
Subjects:
PCSK9
ROS
oxidative stress
platelets
CD36
Online Access:https://www.mdpi.com/2076-3921/9/4/296

Internet

https://www.mdpi.com/2076-3921/9/4/296

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