Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome

Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome

Long-lasting inflammation in the intestinal tract renders individuals susceptible to colitis-associated cancer (CAC). The NOD-like receptor protein 3 (NLRP3) inflammasome plays a key role in the progression of inflammatory bowel disease and CAC. Therefore, identifying effective drugs that prevent CA...

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Bibliographic Details
Main Authors: Guoliang Dai, Zhitao Jiang, Bingting Sun, Chao Liu, Qinghai Meng, Kang Ding, Wen Jing, Wenzheng Ju
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
colitis-associated cancer
NLRP3
caffeic acid phenethyl ester
IL-1β
BMDMs
THP-1 cells
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00721/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00721/full

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