Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[S]

We report in this study an intrinsic link between pyrimidine metabolism and liver lipid accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG. Hepatic microvesicular steatosis is induced by disruption of uridine homeostasis through transgenic overexpression of UPase1, an...

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Bibliographic Details
Main Authors: Thuc T. Le, Amy Ziemba, Yasuyo Urasaki, Eugene Hayes, Steven Brotman, Giuseppe Pizzorno
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422084