Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[S]
We report in this study an intrinsic link between pyrimidine metabolism and liver lipid accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG. Hepatic microvesicular steatosis is induced by disruption of uridine homeostasis through transgenic overexpression of UPase1, an...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-04-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520422084 |