Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

Tauopathies are the most common type of neurodegenerative proteinopathy, being characterized by cytoplasmic aggregates of hyperphosphorylated tau protein. The formation and morphologies of these tau inclusions, the distribution of the lesions and related metabolic changes in cytoplasm differ among d...

Full description

Bibliographic Details
Main Authors: Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C. Robinson, David M. A. Mann, Masato Hasegawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
tauopathy
tau
post-translational modifications
amyloid
fibril structure
cryo-EM
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.581936/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.581936/full

Similar Items