Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug that is reduced to its active metabolite, trans-alcohol form (Trans-OH) by carbonyl reductase enzyme in the liver. Previous studies demonstrated the hydroxylation and glucuronidation of loxoprofen. How...

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Bibliographic Details
Main Authors: Riya Shrestha, Pil Joung Cho, Sanjita Paudel, Aarajana Shrestha, Mi Jeong Kang, Tae Cheon Jeong, Eung-Seok Lee, Sangkyu Lee
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
loxoprofen
CYP
UGT
human liver microsomes
LC-HR/MS
Online Access:http://www.mdpi.com/1999-4923/10/3/112

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http://www.mdpi.com/1999-4923/10/3/112

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