Effect of B7.1 costimulation on T-cell based immunity against TAP-negative cancer can be facilitated by TAP1 expression.

Effect of B7.1 costimulation on T-cell based immunity against TAP-negative cancer can be facilitated by TAP1 expression.

Tumors deficient in expression of the transporter associated with antigen processing (TAP) usually fail to induce T-cell-mediated immunity and are resistant to T-cell lysis. However, we have found that introduction of the B7.1 gene into TAP-negative (TAP(-)) or TAP1-transfected (TAP1(+)) murine lung...

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Bibliographic Details
Main Authors: Xiao-Lin Li, Yong-Yu Liu, David Knight, Yoshinobu Odaka, J Michael Mathis, Runhua Shi, Jonathan Glass, Qian-Jin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2711302?pdf=render

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http://europepmc.org/articles/PMC2711302?pdf=render

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