Drug resistance occurred in a newly characterized preclinical model of lung cancer brain metastasis

Drug resistance occurred in a newly characterized preclinical model of lung cancer brain metastasis

Abstract Background Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion of lung cancer patients (~ 30%). Once diagnosed, patients have a poor p...

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Bibliographic Details
Main Authors: Neal Shah, Zhongwei Liu, Rachel M. Tallman, Afroz Mohammad, Samuel A. Sprowls, Pushkar A. Saralkar, Schuyler D. Vickers, Mark V. Pinti, Weimin Gao, Paul R. Lockman
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Cancer
Subjects:
PC-9
Brain metastasis
Drug resistance
EGFR-TKI
Online Access:http://link.springer.com/article/10.1186/s12885-020-06808-2

Internet

http://link.springer.com/article/10.1186/s12885-020-06808-2

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