Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation

Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation

Hyper-inflammation during acute phase and sequential hypo-inflammation during immunosuppressive phase in macrophages/monocytes lead to multiorgan failure syndrome and immune collapse of sepsis, in which toll-like receptor (TLR)-triggered inflammatory responses play a major role. Here, we reported th...

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Bibliographic Details
Main Authors: Wenqian Li, Yinjiao Li, Kewei Qin, Boxiang Du, Tianliang Li, Hongbin Yuan, Chaofeng Han, Yan Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
Siglec-G
Src homology region 2 domain-containing phosphatase-1
Src
sepsis
pro-inflammatory cytokines
anti-inflammatory cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02575/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02575/full

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