Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia

Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia

Aims: The prolyl-4-hydroxylase domain (PHD) enzymes are representing novel therapeutic targets for ischemic tissue protection. Whereas the consequences of a knock out of the PHDs have been analyzed in the context of cardioprotection, the implications of PHD overexpression is unknown so far. Methods...

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Bibliographic Details
Main Authors: Anke Zieseniss, Amke R. Hesse, Aline Jatho, Sabine Krull, Marion Hölscher, Sabine Vogel, Dörthe M. Katschinski
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hypoxia
Hypoxia-inducible factor
Ischemia
Heart
PHD3
Online Access:http://www.karger.com/Article/FullText/430260

Internet

http://www.karger.com/Article/FullText/430260

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