microRNA-221 Inhibits Latent TGF-β1 Activation through Targeting Thrombospondin-1 to Attenuate Kidney Failure-Induced Cardiac Fibrosis

microRNA-221 Inhibits Latent TGF-β1 Activation through Targeting Thrombospondin-1 to Attenuate Kidney Failure-Induced Cardiac Fibrosis

Kidney failure (KF) is associated with cardiac fibrosis and significantly increased mortality in heart failure. Thrombospondin-1 (TSP1), a key regulator of latent transforming growth factor-β1 (L-TGF-β1) activation, is a predicted target of miR-221. We hypothesized miR-221 attenuates severe KF-assoc...

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Bibliographic Details
Main Authors: Yue Zhou, Denise Yu En Ng, Arthur Mark Richards, Peipei Wang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
microRNA
thrombospondin-1
cardiac fibrosis
kidney failure
latent TGF-β
heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303127

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http://www.sciencedirect.com/science/article/pii/S2162253120303127

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