Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

C. elegans and D. rerio expressing mutant TAR DNA Binding Protein 43 (TDP-43) are powerful in vivo animal models for the genetics and pharmacology of amyotrophic lateral sclerosis (ALS). Using these small-animal models of ALS, we previously identified methylene blue (MB) as a potent suppressor of TD...

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Bibliographic Details
Main Authors: Alexandra Vaccaro, Shunmoogum A. Patten, Dina Aggad, Carl Julien, Claudia Maios, Edor Kabashi, Pierre Drapeau, J. Alex Parker
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neurobiology of Disease
Subjects:
TDP-43
ALS
Genetic models
Small molecules
ER stress
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001034

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http://www.sciencedirect.com/science/article/pii/S0969996113001034

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